2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100664
    Zopiclone N-oxide
    		≥98.0%
    Zopiclone N-oxide (RP 29753) is a less active metabolite of Zopiclone. Zopiclone N-oxide is also an impurity of Eszopiclone and is formed by the oxidation of Eszopiclone.
    Zopiclone N-oxide
  • HY-W008614
    Lansoprazole sulfone
    		99.52%
    Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
    Lansoprazole sulfone
  • HY-137522S
    Zidovudine O-β-D-glucuronide-d3 sodium
    Zidovudine O-β-D-glucuronide-d3 (sodium) (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 (sodium)) is a deuterium labeled Zidovudine O-β-D-glucuronide (sodium) (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
    Zidovudine O-β-D-glucuronide-d<sub>3</sub> sodium
  • HY-131118
    Desmethyl Ketoprofen
    		99.72%
    Desmethyl Ketoprofen has anti-inflammatory activities. Desmethyl Ketoprofen can be used for the study of angiogenesis-related disorders.
    Desmethyl Ketoprofen
  • HY-W002110
    Isohomovanillic acid
    		99.12%
    Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is a product of catecholamine metabolism. Isohomovanillic acid can be isolated from urine. Isohomovanillic acid can be used in the research of Parkinson's disease.
    Isohomovanillic acid
  • HY-109583
    4-Oxofenretinide
    4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9.
    4-Oxofenretinide
  • HY-126857A
    5-Hydroxyomeprazole sodium
    5-Hydroxyomeprazole sodium is the major metabolite of Omeprazole (HY-B0113). Measuring 5-Hydroxyomeprazole levels in plasma can determine the extent of Omeprazole metabolism.
    5-Hydroxyomeprazole sodium
  • HY-U00050S
    (E)-10-Hydroxynortriptyline-d3
    		99.65%
    (E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (E)-10-Hydroxynortriptyline-d<sub>3</sub>
  • HY-101677
    cPrPMEDAP
    		99.62%
    cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin.
    cPrPMEDAP
  • HY-100645
    Trimethoprim 3-oxide
    		≥98.0%
    Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim.
    Trimethoprim 3-oxide
  • HY-137565
    Hydroxy ritonavir
    		99.60%
    Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
    Hydroxy ritonavir
  • HY-141530
    Clopidogrel-β-D-glucuronide
    Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel (HY-15283). Clopidogrel-β-D-glucuronide directly interacts with CYP2C8 enzyme and strongly inhibits the liver enzyme CYP2C8.
    Clopidogrel-β-D-glucuronide
  • HY-101723
    Modecainide
    		99.36%
    Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.
    Modecainide
  • HY-137963
    Daidzein 4'-β-D-glucuronide
    Daidzein 4'-β-D-glucuronide (Compound M4) is a metabolite of Daidzein (HY-N0019).
    Daidzein 4'-β-D-glucuronide
  • HY-135556
    Norfluoxetine
    		98.71%
    Norfluoxetine is the active metabolite of antidepressant Fluoxetine (HY-B0102). Norfluoxetine is a selective inhibitor for serotonin uptake.
    Norfluoxetine
  • HY-137522A
    Zidovudine O-β-D-glucuronide
    Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
    Zidovudine O-β-D-glucuronide
  • HY-130465
    7α-Thiospironolactone
    		99.85%
    7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus.
    7α-Thiospironolactone
  • HY-W008216S
    HMMNI-d3
    		99.90%
    HMMNI-d3 (Hydroxy Dimetridazole-d3) is deuterium labeled HMMNI (HY-W008216). HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class agent that combats protozoan infections.
    HMMNI-d<sub>3</sub>
  • HY-133677S
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4 (MEHHP-d4) is a deuterium labeled Mono(2-ethyl-5-hydroxyhexyl) phthalate (HY-133677). Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-hydroxyhexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d<sub>4</sub>
  • HY-136456
    2-NP-AMOZ
    2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
    2-NP-AMOZ
Cat. No. Product Name / Synonyms Application Reactivity