2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-G0009
    Ritonavir metabolite
    		99.09%
    Ritonavir metabolite is a metabolite of Ritonavir, which is a HIV protease inhibitor.
    Ritonavir metabolite
  • HY-W016033
    Pantoprazole sulfide
    		98.83%
    Pantoprazole sulfide is a metabolite of Pantoprazole (HY-17507), which is a proton-pump inhibitor.
    Pantoprazole sulfide
  • HY-W099331
    Monoethylglycinexylidide hydrochloride
    Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation.
    Monoethylglycinexylidide hydrochloride
  • HY-129072
    Isocyclosporin A
    		98.5%
    Isocyclosporin A is a degradation product of the immunosuppressant Cyclosporin A.
    Isocyclosporin A
  • HY-W010593
    Ethylenethiourea
    		≥98.0%
    Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active.
    Ethylenethiourea
  • HY-W016221S1
    6-Hydroxy Chlorzoxazone-15N,d2
    6-Hydroxy Chlorzoxazone-15N,d2 is the 15N and deuterium labeled 6-Hydroxy Chlorzoxazone (HY-W016221).
    6-Hydroxy Chlorzoxazone-<sup>15</sup>N,d<sub>2</sub>
  • HY-G0003
    Iloperidone metabolite Hydroxy Iloperidone
    		99.97%
    Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is a metabolite of Iloperidone, which is an atypical antipsychotic.
    Iloperidone metabolite Hydroxy Iloperidone
  • HY-W045132
    N-Desbutyl Bupivacaine
    N-Desbutyl Bupivacaine (compound 100) is a metabolite of Bupivacaine (HY-B0405), an NMDA receptor inhibitor and SCN5A antagonist.
    N-Desbutyl Bupivacaine
  • HY-W747072
    3-Sulfo-taurocholic Acid Disodium Salt
    		≥99.0%
    3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.
    3-Sulfo-taurocholic Acid Disodium Salt
  • HY-19657S
    Oxypurinol-13C,15N2
    Oxypurinol-13C,15N2 is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
    Oxypurinol-<sub>13</sub>C,<sub>15</sub>N<sub>2</sub>
  • HY-12767
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
    		98.59%
    4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker.
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
  • HY-G0008A
    O-Desmethyl Mebeverine alcohol hydrochloride
    		≥98.0%
    O-Desmethyl Mebeverine alcohol hydrochloride is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
    O-Desmethyl Mebeverine alcohol hydrochloride
  • HY-15550S1
    4'-Hydroxy diclofenac-13C6
    4'-Hydroxy diclofenac-13C6 is the 13C labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties.
    4'-Hydroxy diclofenac-<sup>13</sup>C<sub>6</sub>
  • HY-I0169
    (R)-Amino-N-benzyl-3-methoxypropionamide
    		99.85%
    (R)-Amino-N-benzyl-3-methoxypropionamide is a stable intermediate of Lacosamide (an antiepileptic drug).
    (R)-Amino-N-benzyl-3-methoxypropionamide
  • HY-130189R
    S-Phenylmercapturic acid (Standard)
    S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
    S-Phenylmercapturic acid (Standard)
  • HY-130569S
    7-Hydroxymethotrexate-d3 sodium
    7-Hydroxymethotrexate-d3 (sodium) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d<sub>3</sub> sodium
  • HY-141626S
    6β-Hydroxytestosterone-d7
    6β-Hydroxytestosterone-d7 is a deuterated labeled 6β-Hydroxytestosterone. 6β-Hydroxytestosterone is a major metabolite of Testosterone.
    6β-Hydroxytestosterone-d<sub>7</sub>
  • HY-B1103R
    Hydroxyhexamide (Standard)
    Hydroxyhexamide (Standard) is an analytical standard for Hydroxyhexamide. This product is intended for research and analytical applications. Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
    Hydroxyhexamide (Standard)
  • HY-B1348R
    Dimethadione (Standard)
    Dimethadione (Standard) is the analytical standard of Dimethadione. This product is intended for research and analytical applications. Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal[1].
    Dimethadione (Standard)
  • HY-133624R
    1,1,3-Tribromoacetone (Standard)
    1,1,3-Tribromoacetone (Standard) is the analytical standard of 1,1,3-Tribromoacetone. This product is intended for research and analytical applications. 1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519)[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].
    1,1,3-Tribromoacetone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity